Richard E Klabunde – Pathophysiology of Heart Failure

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Implications for Systolic and Diastolic Dysfunction

Learning Objectives:

• Describe the pressure and volume changes in a normal ventricle during the cardiac cycle
• Describe the relationship between stroke volume and pre-load
• Define heart failure caused by ventricular systolic and diastolic dysfunction
• List common causes of systolic and diastolic dysfunction and possible intracellular mechanisms
• Contrast intracardiac pressure and volume changes, and structural changes associated with systolic and diastolic dysfunction
• Describe the physiologic basis of different treatment modalities for improving ventricular function implications for Systolic and Diastolic Dysfunction

Presently, Dr. Klabunde is a professor of physiology at Marian University College of Osteopathic Medicine (MUCOM) in Indianapolis, IN. He received his Ph.D. in physiology from the University of Arizona in Tucson, followed by postdoctoral training in pharmacology at the University of California in San Diego. Dr. Klabunde’s academic research focused on regulation of skeletal muscle and coronary circulation, and cardiac function. In 2012, he was awarded the Arthur C. Guyton Physiology Educator of the Year Award from the American Physiological Society. He has published more than 50 research articles and two textbooks on cardiovascular physiology and manages the content of two cardiovascular teaching websites.

Dr. Klabunde discloses that he has no relevant financial relationships with any organization producing, marketing, reselling, or distributing health care goods or services consumed by, or used on, patients relative to the content of this presentation.

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